AGTR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AGTR1.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human AGTR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Immunofluorescence (20 ug/mL)
Immunohistochemistry (2.5 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of AGTR1 in mouse kidney tissue lysate with AGTR1 polyclonal antibody (Cat # PAB16828) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemical staining of mouse kidney tissue with 2.5 ug/mL AGTR1 polyclonal antibody (Cat # PAB16828).Immunofluorescence
Immunofluorescence staining of mouse kidney cells with AGTR1 polyclonal antibody (Cat # PAB16828) under 20 ug/mL working concentration.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AGTR1
Entrez GeneID
185Protein Accession#
EAW78909Gene Name
AGTR1
Gene Alias
AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R
Gene Description
angiotensin II receptor, type 1
Gene Ontology
HyperlinkGene Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq
Other Designations
angiotensin receptor 1|angiotensin receptor 1B|type-1B angiotensin II receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D.
FEBS Open Bio 2014 Apr; 4:353.
Application:IHC, WB-Tr, Human, Hep3B-Con, QGY-Consi, Huh7 cells, Hepatocellular carcinoma.
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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
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