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Last updated: 2016/12/4
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HAAO polyclonal antibody

  • Catalog # : PAB16785
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of HAAO.
  • Immunogen:
  • A synthetic peptide corresponding to N-terminus 17 amino acids of human HAAO.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of HAAO in mouse liver tissue lysate with HAAO polyclonal antibody (Cat # PAB16785) at 1 ug/mL .
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemistry of HAAO in human liver tissue with HAAO polyclonal antibody (Cat # PAB16785) at 2.5 ug/mL .
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • HAAO
  • Gene Alias:
  • 3-HAO,HAO
  • Gene Description:
  • 3-hydroxyanthranilate 3,4-dioxygenase
  • Gene Summary:
  • 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq
  • Other Designations:
  • 3-hydroxyanthranilate oxygenase,3-hydroxyanthranilic acid dioxygenase
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