HAAO polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of HAAO in mouse liver tissue lysate with HAAO polyclonal antibody (Cat # PAB16785) at 1 ug/mL .
Immunohistochemistry
Immunohistochemistry of HAAO in human liver tissue with HAAO polyclonal antibody (Cat # PAB16785) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HAAO.
Immunogen
A synthetic peptide corresponding to N-terminus 17 amino acids of human HAAO.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HAAO in mouse liver tissue lysate with HAAO polyclonal antibody (Cat # PAB16785) at 1 ug/mL .Immunohistochemistry
Immunohistochemistry of HAAO in human liver tissue with HAAO polyclonal antibody (Cat # PAB16785) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — HAAO
Entrez GeneID
23498Protein Accession#
NP_036337Gene Name
HAAO
Gene Alias
3-HAO, HAO
Gene Description
3-hydroxyanthranilate 3,4-dioxygenase
Omim ID
604521Gene Ontology
HyperlinkGene Summary
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq
Other Designations
3-hydroxyanthranilate oxygenase|3-hydroxyanthranilic acid dioxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of candidate epigenetic biomarkers for ovarian cancer detection.
Huang YW, Jansen RA, Fabbri E, Potter D, Liyanarachchi S, Chan MW, Liu JC, Crijns AP, Brown R, Nephew KP, van der Zee AG, Cohn DE, Yan PS, Huang TH, Lin HJ.
Oncology Reports 2009 Oct; 22(4):853.
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Purification and properties of 3-hydroxyanthranilic acid oxidase.
DECKER RH, KANG HH, LEACH FR, HENDERSON LM.
The Journal of Biological Chemistry 1961 Nov; 236:3076.
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Identification of candidate epigenetic biomarkers for ovarian cancer detection.
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