THEM4 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of THEM4.
Immunogen
A synthetic peptide corresponding to internal region 18 amino acids of human THEM4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of THEM4 in human liver tissue lysate with THEM4 polyclonal antibody (Cat # PAB16766) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of THEM4 in human liver tissue with THEM4 polyclonal antibody (Cat # PAB16766) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — THEM4
Entrez GeneID
117145Protein Accession#
NP_444283Gene Name
THEM4
Gene Alias
CTMP, MGC29636
Gene Description
thioesterase superfamily member 4
Omim ID
606388Gene Ontology
HyperlinkGene Summary
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq
Other Designations
C-terminal modulator protein|OTTHUMP00000015248
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Interactomes
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Publication Reference
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The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.
Zhao H, Martin BM, Bisoffi M, Dunaway-Mariano D.
Biochemistry 2009 Jun; 48(24):5507.
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Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.
Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA.
Cellular Signalling 2009 Jan; 21(4):639.
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Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas.
Knobbe CB, Reifenberger J, Blaschke B, Reifenberger G.
Journal of the National Cancer Institute 2004 Mar; 96(6):483.
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The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.
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