SHOC2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SHOC2.
Immunogen
A synthetic peptide corresponding to N-terminus 21 amino acids of human SHOC2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SHOC2 in Jurkat cell lysate with SHOC2 polyclonal antibody (Cat # PAB16760) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of SHOC2 in human spleen tissue with SHOC2 polyclonal antibody (Cat # PAB16760) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SHOC2
Entrez GeneID
8036Protein Accession#
NP_031399Gene Name
SHOC2
Gene Alias
FLJ60412, KIAA0862, SIAA0862, SOC-2, SOC2, SUR-8, SUR8
Gene Description
soc-2 suppressor of clear homolog (C. elegans)
Omim ID
602775Gene Ontology
HyperlinkGene Summary
C. elegans
Other Designations
OTTHUMP00000020481|soc-2 suppressor of clear homolog|suppressor of clear, C. elegans, homolog of
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Interactome
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Publication Reference
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A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F.
Molecular Cell 2006 Apr; 22(2):217.
Application:IP, WB-Tr, Human, A-427, A-549, ASPC1, HEK 293T, HeLa, HepG2, HPAF, HT1080, MDA-MB-231, MiaPaca1, PANC1, RD, SKMEL-2, SW480 cells.
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The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Li W, Han M, Guan KL.
Genes & Development 2000 Apr; 14(8):895.
Application:IP, Human, HEK 293 cells.
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soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Selfors LM, Schutzman JL, Borland CZ, Stern MJ.
PNAS 1998 Jun; 95(12):6903.
Application:IF, IP-WB, Mouse, Monkey, COS-7, NIH/3T3 cells.
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A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
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