MACC1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MACC1.
Immunogen
A synthetic peptide corresponding to internal region 17 amino acids of human MACC1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 polyclonal antibody (Cat # PAB16755) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of MACC1 in human lung tissue with MACC1 polyclonal antibody (Cat # PAB16755) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — MACC1
Entrez GeneID
346389Protein Accession#
AJ313524Gene Name
MACC1
Gene Alias
7A5, SH3BP4L
Gene Description
metastasis associated in colon cancer 1
Gene Ontology
HyperlinkGene Summary
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM
Other Designations
putative binding protein 7a5
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Publication Reference
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A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway.
Liu J, Pan C, Guo L, Wu M, Guo J, Peng S, Wu Q, Zuo Q.
International Journal of Hematologic Oncology 2016 Aug; 9(1):76.
Application:WB-Tr, IHC-P, Human, NCI-N87, MKN45 cells, Mouse NCI-N87-xenografts tumor tissue.
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MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect.
Lin L, Huang H, Liao W, Ma H, Liu J, Wang L, Huang N, Liao Y, Liao W.
Oncogene 2015 May; 34(21):2700.
Application:WB-Ce, Human, BGC-823 cells.
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Overexpression of Metastasis-Associated in Colon Cancer-1 Associated with Poor Prognosis in Patients with Esophageal Cancer.
Zhu M, Xu Y, Mao X, Gao Y, Shao L, Yan F.
Pathology Oncology Research 2013 Oct; 19(4):749.
Application:IHC-P, Human, Esophageal cancer.
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MACC1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion.
Wang L, Wu Y, Lin L, Liu P, Huang H, Liao W, Zheng D, Zuo Q, Sun L, Huang N, Shi M, Liao Y, Liao W.
International Journal of Cancer 2013 Sep; 133(6):1419.
Application:IHC,WB, Human, Human Gastric cells (IHC) , BGC-823 cells (WB), MKN cells (WB).
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MACC1 controls Met: what a difference an Sp1 site makes.
Stein U, Smith J, Walther W, Arlt F.
Cell Cycle 2009 Aug; 8(15):2467.
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Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer.
Boardman LA.
Genome Medicine 2009 Apr; 1(4):36.
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MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM.
Nature Medicine 2009 Jan; 15(1):59.
Application:IF, IHC, WB-Tr, Human, Human colon cancer, SW480 cells.
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A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway.
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