RSPO1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of RSPO1 in rat spleen tissue lysate with RSPO1 polyclonal antibody (Cat # PAB16747) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of RSPO1 in human spleen tissue with RSPO1 polyclonal antibody (Cat # PAB16747) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RSPO1.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human RSPO1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of RSPO1 in rat spleen tissue lysate with RSPO1 polyclonal antibody (Cat # PAB16747) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of RSPO1 in human spleen tissue with RSPO1 polyclonal antibody (Cat # PAB16747) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — RSPO1
Entrez GeneID
284654Protein Accession#
NP_001033722Gene Name
RSPO1
Gene Alias
CRISTIN3, FLJ40906, RSPO
Gene Description
R-spondin homolog (Xenopus laevis)
Omim ID
609595Gene Ontology
HyperlinkGene Summary
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq
Other Designations
OTTHUMP00000180612|OTTHUMP00000180613|R-spondin1|roof plate-specific spondin
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Interactome
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Publication Reference
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Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC.
Human Molecular Genetics 2008 May; 17(9):1264.
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R-spondin1 is essential in sex determination, skin differentiation and malignancy.
Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G.
Nature Genetics 2006 Nov; 38(11):1304.
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R-Spondin proteins: a novel link to beta-catenin activation.
Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
Cell Cycle (Georgetown, Tex.) 2006 Jan; 5(1):23.
Application：WB-Tr, Human, HeLa cells.
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Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
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