ST3GAL6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ST3GAL6.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human ST3GAL6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ST3GAL6 in HeLa cell lysate with ST3GAL6 polyclonal antibody (Cat # PAB16746) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of ST3GAL6 in HeLa cells with ST3GAL6 polyclonal antibody (Cat # PAB16746) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — ST3GAL6
Entrez GeneID
10402Protein Accession#
NP_006091Gene Name
ST3GAL6
Gene Alias
SIAT10, ST3GALVI
Gene Description
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Omim ID
607156Gene Ontology
HyperlinkGene Summary
Sialyltransferases, such as ST3GAL6, catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types.[supplied by OMIM
Other Designations
alpha2,3-sialyltransferase|alpha2,3-sialyltransferase VI|sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
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Interactome
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Pathway
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Disease
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Publication Reference
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DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T.
Gastroenterology 2008 Jul; 135(1):142.
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Sialyltransferases in cancer.
Dall'Olio F, Chiricolo M.
Glycoconj J 2001 Nov; 18(11-12):841.
Application:WB, Human, Cancers.
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Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.
Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T, Furukawa K.
The Journal of Biological Chemistry 1999 Apr; 274(17):11479.
Application:WB, Human, Human red blood cells, Sialic acid-incorporated products.
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DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
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