SH3BP4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SH3BP4.
Immunogen
A synthetic peptide corresponding to C-terminus 18 amino acids of human SH3BP4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SH3BP4 in rat lung tissue lysate with SH3BP4 polyclonal antibody (Cat # PAB16745) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of SH3BP4 in human lung tissue with SH3BP4 polyclonal antibody (Cat # PAB16745) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SH3BP4
Entrez GeneID
23677Protein Accession#
NP_055336Gene Name
SH3BP4
Gene Alias
BOG25, TTP
Gene Description
SH3-domain binding protein 4
Omim ID
605611Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq
Other Designations
EH-binding protein|OTTHUMP00000164396|transferrin receptor trafficking protein
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Interactome
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Disease
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Publication Reference
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TTP specifically regulates the internalization of the transferrin receptor.
Tosoni D, Puri C, Confalonieri S, Salcini AE, De Camilli P, Tacchetti C, Di Fiore PP.
Cell 2005 Dec; 123(5):875.
Application:IF, IP-WB, WB-Ce, WB-Tr, WB-Ti, Human, Rat, HeLa cells.
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Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts.
Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR.
Genomics 1999 Dec; 62(3):519.
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TTP specifically regulates the internalization of the transferrin receptor.
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