FTO polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FTO.
Immunogen
A synthetic peptide corresponding to N-terminus 15 amino acids of human FTO.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of FTO in human uterus tissue lysate with FTO polyclonal antibody (Cat # PAB16736) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of FTO in mouse brain tissue with FTO polyclonal antibody (Cat # PAB16736) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
-
Gene Info — FTO
Entrez GeneID
79068Protein Accession#
Q9C0B1Gene Name
FTO
Gene Alias
KIAA1752, MGC5149
Gene Description
fat mass and obesity associated
Gene Ontology
HyperlinkGene Summary
The exact function of this gene is not know. Studies in mice suggest that it may be involved in nucleic acid demethylation, and that its mRNA level is regulated by feeding and fasting. Genomewide association studies of type 2 diabetes indicate this gene as a diabetes susceptibility locus. Mutation in this gene has been associated with growth retardation, developmental delay, coarse facies, and early death. [provided by RefSeq
Other Designations
-
-
Interactome
-
Disease
- Anorexia Nervosa
- Appetite
- Asthma
- Atherosclerosis
- Birth Weight
- Calcinosis
- Carcinoma
- Cardiovascular Diseases
- Cataract
+ View More Disease
-
Publication Reference
-
Regulation of Fto/Ftm gene expression in mice and humans.
Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2008 Apr; 294(4):R1185.
-
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.
Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J, Schioth HB.
Endocrinology 2008 May; 149(5):2062.
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orru M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR.
PLoS Genetics 2007 Jul; 3(7):e115.
-
Regulation of Fto/Ftm gene expression in mice and humans.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com