PCDH12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PCDH12 in K-562 cell lysate with PCDH12 polyclonal antibody (Cat # PAB16714) at 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of PCDH12 in rat lung tissue with PCDH12 polyclonal antibody (Cat # PAB16714) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PCDH12.
Immunogen
A synthetic peptide corresponding to N-terminus 17 amino acids of human PCDH12.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PCDH12 in K-562 cell lysate with PCDH12 polyclonal antibody (Cat # PAB16714) at 2 ug/mL .Immunohistochemistry
Immunohistochemistry of PCDH12 in rat lung tissue with PCDH12 polyclonal antibody (Cat # PAB16714) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PCDH12
Entrez GeneID
51294Protein Accession#
NP_057664Gene Name
PCDH12
Gene Alias
VE-cadherin-2, VECAD2
Gene Description
protocadherin 12
Omim ID
605622Gene Ontology
HyperlinkGene Summary
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq
Other Designations
VE-cadherin 2|vascular cadherin-2|vascular endothelial cadherin 2
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Interactome
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Disease
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Publication Reference
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Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.
Rampon C, Bouillot S, Climescu-Haulica A, Prandini MH, Cand F, Vandenbrouck Y, Huber P.
Physiological Genomics 2008 Jul; 34(2):193.
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Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells.
Rampon C, Prandini MH, Bouillot S, Pointu H, Tillet E, Frank R, Vernet M, Huber P.
Experimental Cell Research 2005 Jan; 302(1):48.
Application：IHC-Fr, IP, WB-Ti, Mouse, Embryo, Eyes, Deciduum, H5V cells, Ovaries, Placenta, Spleen.
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Protocadherins.
Frank M, Kemler R.
Current Opinion in Cell Biology 2002 Oct; 14(5):557.
Application：IHC, WB, Human, Mammalian cells.
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Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.
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