ZFYVE26 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ZFYVE26.
Immunogen
A synthetic peptide corresponding C-terminus to 16 amino acids of human ZFYVE26.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ZFYVE26 in rat heart tissue lysate with ZFYVE26 polyclonal antibody (Cat # PAB16701) at (A) 0.5 and (B) 1 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — ZFYVE26
Entrez GeneID
23503Protein Accession#
EAW80952Gene Name
ZFYVE26
Gene Alias
DKFZp686F19106, DKFZp781H1112, KIAA0321, SPG15
Gene Description
zinc finger, FYVE domain containing 26
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq
Other Designations
spastizin
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Interactome
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Disease
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Publication Reference
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Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population.
Denora PS, Muglia M, Casali C, Truchetto J, Silvestri G, Messina D, Boukrhis A, Magariello A, Modoni A, Masciullo M, Malandrini A, Morelli M, de Leva MF, Villanova M, Giugni E, Citrigno L, Rizza T, Federico A, Pierallini A, Quattrone A, Filla A, Brice A, Stevanin G, Santorelli FM.
Journal of the Neurological Sciences 2009 Feb; 277(1-2):22.
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Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.
Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, Benomar A, Lossos A, Denora P, Fernandez J, Elleuch N, Forlani S, Durr A, Feki I, Hutchinson M, Santorelli FM, Mhiri C, Brice A, Stevanin G.
American Journal of Human Genetics 2008 Apr; 82(4):992.
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Spastic paraplegia 15: linkage and clinical description of three Tunisian families.
Boukhris A, Feki I, Denis E, Miladi MI, Brice A, Mhiri C, Stevanin G.
Movement Disorders: Official Journal of the Movement Disorder Society 2008 Feb; 23(3):429.
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Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population.
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