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RNASEH2A polyclonal antibody

  • Catalog # : PAB16685
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of RNASEH2A.
  • Immunogen:
  • A synthetic peptide corresponding to internal region 17 amino acids of human RNASEH2A.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 2.
  • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection.
    Crow YJ, Leitch A, Hayward BE, Garner A, Parmar R, Griffith E, Ali M, Semple C, Aicardi J, Babul-Hirji R, Baumann C, Baxter P, Bertini E, Chandler KE, Chitayat D, Cau D, Dery C, Fazzi E, Goizet C, King MD, Klepper J, Lacombe D, Lanzi G, Lyall H, Martinez-Frias ML, Mathieu M, McKeown C, Monier A, Oade Y, Quarrell OW, Rittey CD, Rogers RC, Sanchis A, Stephenson JB, Tacke U, Till M, Tolmie JL, Tomlin P, Voit T, Weschke B, Woods CG, Lebon P, Bonthron DT, Ponting CP, Jackson AP.Nat Genet. 2006 Aug;38(8):910-6. Epub 2006 Jul 16.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of RNASEH2A in HeLa cell lysate with RNASEH2A polyclonal antibody (Cat # PAB16685) at 1 ug/mL .
  • Immunocytochemistry
  • Immunocytochemistry
  • Immunocytochemistry of RNASEH2A in HeLa cells with RNASEH2A polyclonal antibody (Cat # PAB16685) at 2 ug/mL .
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • RNASEH2A
  • Gene Alias:
  • AGS4,JUNB,RNASEHI,RNHIA,RNHL
  • Gene Description:
  • ribonuclease H2, subunit A
  • Gene Summary:
  • The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid
  • Other Designations:
  • ribonuclease H2, large subunit,ribonuclease HI, large subunit
  • Gene Pathway
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