RNASEH2A polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of RNASEH2A in HeLa cell lysate with RNASEH2A polyclonal antibody (Cat # PAB16685) at 1 ug/mL .
Immunocytochemistry
Immunocytochemistry of RNASEH2A in HeLa cells with RNASEH2A polyclonal antibody (Cat # PAB16685) at 2 ug/mL .
-
Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RNASEH2A.
Immunogen
A synthetic peptide corresponding to internal region 17 amino acids of human RNASEH2A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of RNASEH2A in HeLa cell lysate with RNASEH2A polyclonal antibody (Cat # PAB16685) at 1 ug/mL .Immunocytochemistry
Immunocytochemistry of RNASEH2A in HeLa cells with RNASEH2A polyclonal antibody (Cat # PAB16685) at 2 ug/mL .Enzyme-linked Immunoabsorbent Assay
-
Gene Info — RNASEH2A
Entrez GeneID
10535Protein Accession#
O75792Gene Name
RNASEH2A
Gene Alias
AGS4, JUNB, RNASEHI, RNHIA, RNHL
Gene Description
ribonuclease H2, subunit A
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid
Other Designations
ribonuclease H2, large subunit|ribonuclease HI, large subunit
-
Interactomes
-
Pathways
-
Publication Reference
-
Ribonuclease H: the enzymes in eukaryotes.
Cerritelli SM, Crouch RJ.
FEBS Letters 2009 Mar; 276(6):1494.
-
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection.
Crow YJ, Leitch A, Hayward BE, Garner A, Parmar R, Griffith E, Ali M, Semple C, Aicardi J, Babul-Hirji R, Baumann C, Baxter P, Bertini E, Chandler KE, Chitayat D, Cau D, Dery C, Fazzi E, Goizet C, King MD, Klepper J, Lacombe D, Lanzi G, Lyall H, Martinez-Frias ML, Mathieu M, McKeown C, Monier A, Oade Y, Quarrell OW, Rittey CD, Rogers RC, Sanchis A, Stephenson JB, Tacke U, Till M, Tolmie JL, Tomlin P, Voit T, Weschke B, Woods CG, Lebon P, Bonthron DT, Ponting CP, Jackson AP.
Nature Genetics 2006 Aug; 38(8):910.
-
RNase H2 of Saccharomyces cerevisiae is a complex of three proteins.
Jeong HS, Backlund PS, Chen HC, Karavanov AA, Crouch RJ.
Nucleic Acids Research 2004 Jan; 32(2):407.
-
Ribonuclease H: the enzymes in eukaryotes.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com