EBI3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of EBI3 in rat spleen tissue lysate with EBI3 polyclonal antibody (Cat # PAB16684) at 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of EBI3 in human spleen tissue with EBI3 polyclonal antibody (Cat # PAB16684) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EBI3.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human EBI3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of EBI3 in rat spleen tissue lysate with EBI3 polyclonal antibody (Cat # PAB16684) at 2 ug/mL .Immunohistochemistry
Immunohistochemistry of EBI3 in human spleen tissue with EBI3 polyclonal antibody (Cat # PAB16684) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — EBI3
Entrez GeneID
10148Protein Accession#
NP_005746Gene Name
EBI3
Gene Alias
IL27B
Gene Description
Epstein-Barr virus induced 3
Omim ID
605816Gene Ontology
HyperlinkGene Summary
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq
Other Designations
Epstein-Barr virus induced gene 3|cytokine receptor|interleukin-27 subunit beta
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Interactome
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Publication Reference
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IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells.
Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY.
European Journal of Immunology 2007 Nov; 37(11):3021.
Application：WB-Re, Recombinant protein.
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WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.
Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.
Journal of Immunology 2004 Feb; 172(4):2225.
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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.
Immunity 2002 Jun; 16(6):779.
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IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells.
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