TREX2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TREX2.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human TREX2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 polyclonal antibody (Cat # PAB16682) at 2.5 ug/mL .Immunohistochemistry
Immunohistochemistry of TREX2 in human liver tissue with TREX2 polyclonal antibody (Cat # PAB16682) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — TREX2
Entrez GeneID
11219Protein Accession#
Q9BQ50Gene Name
TREX2
Gene Alias
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Gene Description
three prime repair exonuclease 2
Omim ID
300370Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq
Other Designations
3'-5' exonuclease|OTTHUMP00000025920|OTTHUMP00000025922
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Interactome
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Disease
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Publication Reference
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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus.
Crow YJ, Hayward BE, Parmar R, Robins P, Leitch A, Ali M, Black DN, van Bokhoven H, Brunner HG, Hamel BC, Corry PC, Cowan FM, Frints SG, Klepper J, Livingston JH, Lynch SA, Massey RF, Meritet JF, Michaud JL, Ponsot G, Voit T, Lebon P, Bonthron DT, Jackson AP, Barnes DE, Lindahl T.
Nature Genetics 2006 Aug; 38(8):917.
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ATR and ATRIP: partners in checkpoint signaling.
Cortez D, Guntuku S, Qin J, Elledge SJ.
Science 2001 Nov; 294(5547):1713.
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Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.
Mazur DJ, Perrino FW.
The Journal of Biological Chemistry 2001 May; 276(18):14718.
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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus.
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