GGCX polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GGCX.
Immunogen
A synthetic peptide corresponding to human GGCX.
Sequence
C-PPESNPDPVHSE
Host
Goat
Theoretical MW (kDa)
87.6, 81
Reactivity
Human
Specificity
This antibody is expected to recognize both isoforms (NP_000812.2; NP_001135741.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GGCX polyclonal antibody (Cat # PAB16633) (0.3 ug/mL) staining of human muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GGCX
Entrez GeneID
2677Protein Accession#
NP_000812.2;NP_001135741.1Gene Name
GGCX
Gene Alias
FLJ26629, VKCFD1
Gene Description
gamma-glutamyl carboxylase
Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
vitamin K-dependent gamma-carboxylase
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Interactome
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Disease
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Publication Reference
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Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.
Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J.
The Journal of Investigative Dermatology 2009 Mar; 129(3):553.
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Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.
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