IGF2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial synthetic protein of IGF2.
Immunogen
Synthetic protein corresponding to C-terminus IGF2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
ELISA (1-2 ug/mL)
Immunohistochemistry (2-10 ug/mL)
Western Blot (2-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.4 (50% glycerol, 1% BSA, 0.03% proclin).
Storage Instruction
Store at 2-8°C for one month, or at -20°C for 12 months without detectable loss of activity.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunohistochemical analysis of IGF2 expression in human ovarian vascular endothelial cells. IGF2 polyclonal antibody (Cat ID # PAB16615) was used as primary antibody, dilution 1 : 200.Immunohistochemistry
Immunohistochemical analysis of IGF2 expression in human breast carcinoma tissue. IGF2 polyclonal antibody (Cat ID # PAB16615) was used as primary antibody, dilution 1 : 200.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IGF2
Entrez GeneID
3481Protein Accession#
P01344Gene Name
IGF2
Gene Alias
C11orf43, FLJ22066, FLJ44734, INSIGF, pp9974
Gene Description
insulin-like growth factor 2 (somatomedin A)
Omim ID
147470Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Alternatively spliced transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000011012|OTTHUMP00000011015|OTTHUMP00000011018|OTTHUMP00000011157|insulin-like growth factor 2|insulin-like growth factor II|insulin-like growth factor type 2|putative insulin-like growth factor II associated protein|somatomedin A
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Interactome
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Disease
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Publication Reference
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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.
Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.
PNAS 2009 Sep; 106(40):17031.
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The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8.
Im E, Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH.
American Journal of Physiology. Gastrointestinal and Liver Physiology 2009 Nov; 297(5):G999.
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IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung.
Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2009 Jul; 297(3):L512.
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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.
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