IGF1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic protein of IGF1.
Immunogen
Synthetic protein corresponding to IGF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Protein G affinity chromatography
Isotype
IgG
Recommend Usage
ELISA (1-2 ug/mL)
Immunohistochemistry (2-10 ug/mL)
Western Blot (0.1-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from TBS, pH 7.4.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with PBS pH 7.4 or other diluents (such as distilled water), store at 2-8°C for one month, or at -20°C for six months without detectable loss of activity.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunohistochemical analysis of IGFI expression in NZ rabbit knee joint tissue. IGF1 polyclonal antibody (Cat ID # PAB16614) was used as primary antibody, dilution 1 : 200.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IGF1
Entrez GeneID
3479Protein Accession#
P01343Gene Name
IGF1
Gene Alias
IGFI
Gene Description
insulin-like growth factor 1 (somatomedin C)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene
Other Designations
insulin-like growth factor 1|somatomedin C
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Interactome
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Pathway
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Disease
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Publication Reference
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Hypoactivity Affects IGF-1 Level and PI3K/AKT Signaling Pathway in Cerebral Structures Implied in Motor Control.
Mysoet J, Canu MH, Cieniewski-Bernard C, Bastide B, Dupont E.
PloS One 2014 Sep; 9(9):e107631.
Application:WB, Rat, Plasma.
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IGF-I lucidity ... the murky waters begin to clear?
Spangenburg EE.
Journal of Applied Physiology 2010 Mar; 108(5):1032.
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A significant decline in IGF-I may predispose young Africans to subsequent cardiometabolic vulnerability.
Schutte AE, Huisman HW, van Rooyen JM, Malan L, Malan NT, Fourie CM, Louw R, van der Westhuizen FH, Schutte R.
The Journal of Clinical Endocrinology and Metabolism 2010 Mar; 95(5):2503.
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Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.
Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS.
The Journal of Biological Chemistry 2009 Dec; 285(12):8743.
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Hypoactivity Affects IGF-1 Level and PI3K/AKT Signaling Pathway in Cerebral Structures Implied in Motor Control.
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