JPH2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of JPH2.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human JPH2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of JPH2 in mouse brain tissue lysate with JPH2 polyclonal antibody (Cat # PAB16596) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of JPH2 in mouse skeletal muscle tissue with JPH2 polyclonal antibody (Cat # PAB16596) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — JPH2
Entrez GeneID
57158Protein Accession#
NP_065166Gene Name
JPH2
Gene Alias
FLJ40969, JP-2, JP2
Gene Description
junctophilin 2
Omim ID
605267Gene Ontology
HyperlinkGene Summary
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq
Other Designations
OTTHUMP00000031651|OTTHUMP00000031652
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Interactome
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Disease
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Publication Reference
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Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy.
Matsushita Y, Furukawa T, Kasanuki H, Nishibatake M, Kurihara Y, Ikeda A, Kamatani N, Takeshima H, Matsuoka R.
Journal of Human Genetics 2007 May; 52(6):543.
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Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H.
The EMBO Journal 2007 Mar; 26(7):1924.
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Coexpression of junctophilin type 3 and type 4 in brain.
Nishi M, Sakagami H, Komazaki S, Kondo H, Takeshima H.
Brain Research. Molecular Brain Research 2003 Oct; 118(1-2):102.
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Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy.
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