JPH3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of JPH3 in Daudi cell lysate with JPH3 polyclonal antibody (Cat # PAB16594) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry
Immunohistochemistry of JPH3 in human brain tissue with JPH3 polyclonal antibody (Cat # PAB16594) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of JPH3.
Immunogen
A synthetic peptide corresponding to C-terminus 18 amino acids of human JPH3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of JPH3 in Daudi cell lysate with JPH3 polyclonal antibody (Cat # PAB16594) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.Immunohistochemistry
Immunohistochemistry of JPH3 in human brain tissue with JPH3 polyclonal antibody (Cat # PAB16594) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — JPH3
Entrez GeneID
57338Protein Accession#
NP_065706Gene Name
JPH3
Gene Alias
CAGL237, FLJ44707, HDL2, JP-3, JP3, TNRC22
Gene Description
junctophilin 3
Gene Ontology
HyperlinkGene Summary
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family. [provided by RefSeq
Other Designations
junctophilin type 3|trinucleotide repeat containing 22
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Interactome
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Disease
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Publication Reference
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Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H.
The EMBO Journal 2007 Mar; 26(7):1924.
Application：WB-Ti, Mouse, Mouse cerebellum.
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Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H.
PNAS 2006 Jun; 103(28):10811.
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Coexpression of junctophilin type 3 and type 4 in brain.
Nishi M, Sakagami H, Komazaki S, Kondo H, Takeshima H.
Brain Research. Molecular Brain Research 2003 Oct; 118(1-2):102.
Application：WB-Ti, Mouse, Mouse brain, liver, kidney.
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Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
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