STK39 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of STK39 in rat brain tissue lysate with STK39 polyclonal antibody (Cat # PAB16586) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of STK39 in human brain tissue with STK39 polyclonal antibody (Cat # PAB16586) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK39.
Immunogen
A synthetic peptide corresponding to internal region 18 amino acids of human STK39.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of STK39 in rat brain tissue lysate with STK39 polyclonal antibody (Cat # PAB16586) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of STK39 in human brain tissue with STK39 polyclonal antibody (Cat # PAB16586) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — STK39
Entrez GeneID
27347Protein Accession#
NP_037365Gene Name
STK39
Gene Alias
DCHT, DKFZp686K05124, PASK, SPAK
Gene Description
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
Omim ID
607648Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq
Other Designations
Ste20-like protein kinase|proline-alanine-rich STE20-related kinase|small intestine SPAK-like kinase
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Interactome
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Disease
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Publication Reference
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Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
Gagnon KB, England R, Delpire E.
Molecular and Cellular Biology 2006 Jan; 26(2):689.
Application：WB-Re, Recombinant protein.
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SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.
Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A.
The EMBO Journal 2004 Mar; 23(5):1112.
Application：IP, WB-Ce, WB-Tr, Human, Jurkat E6.1 cells.
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The Ste20 group kinases as regulators of MAP kinase cascades.
Dan I, Watanabe NM, Kusumi A.
Trends in Cell Biology 2001 May; 11(5):220.
Application：WB-Tr, Human, Mammalican cells.
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Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
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