AIPL1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of AIPL1 in rat brain tissue lysate with AIPL1 polyclonal antibody (Cat # PAB16585) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of AIPL1 in human brain tissue with AIPL1 polyclonal antibody (Cat # PAB16585) at 2.5 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AIPL1.
Immunogen
A synthetic peptide corresponding to internal region 18 amino acids of human AIPL1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of AIPL1 in rat brain tissue lysate with AIPL1 polyclonal antibody (Cat # PAB16585) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of AIPL1 in human brain tissue with AIPL1 polyclonal antibody (Cat # PAB16585) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
-
Gene Info — AIPL1
Entrez GeneID
23746Protein Accession#
NP_055151Gene Name
AIPL1
Gene Alias
AIPL2, LCA4
Gene Description
aryl hydrocarbon receptor interacting protein-like 1
Gene Ontology
HyperlinkGene Summary
Leber congenital amaurosis (LCA) accounts for at least 5% of all inherited retinal disease and is the most severe inherited retinopathy with the earliest age of onset. Individuals affected with LCA are diagnosed at birth or in the first few months of life with severely impaired vision or blindness, nystagmus and an abnormal or flat electroretinogram. The photoreceptor/pineal -expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, was mapped within the LCA4 candidate region. The protein contains three tetratricopeptide motifs, consistent with nuclear transport or chaperone activity. AIPL1 mutations may cause approximately 20% of recessive LCA. [provided by RefSeq
Other Designations
-
-
Interactome
-
Disease
-
Publication Reference
-
The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.
Hidalgo-de-Quintana J, Evans RJ, Cheetham ME, van der Spuy J.
Investigative Ophthalmology & Visual Science 2008 Jul; 49(7):2878.
Application：WB, Human, Y79 cells.
-
The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.
Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM.
Human Molecular Genetics 2002 Oct; 11(22):2723.
Application：IF, IHC, IP, IP-WB, Human, Y79 retinoblastoma cells, Retina.
-
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Sohocki MM, Bowne SJ, Sullivan LS, Blackshaw S, Cepko CL, Payne AM, Bhattacharya SS, Khaliq S, Qasim Mehdi S, Birch DG, Harrison WR, Elder FF, Heckenlively JR, Daiger SP.
Nature Genetics 2000 Jan; 24(1):79.
-
The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com