SPRED1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SPRED1 in human brain tissue lysate with SPRED1 polyclonal antibody (Cat # PAB16582) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of SPRED1 in human brain tissue with SPRED1 polyclonal antibody (Cat # PAB16582) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPRED1.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human SPRED1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SPRED1 in human brain tissue lysate with SPRED1 polyclonal antibody (Cat # PAB16582) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of SPRED1 in human brain tissue with SPRED1 polyclonal antibody (Cat # PAB16582) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPRED1
Entrez GeneID
161742Protein Accession#
NP_689807Gene Name
SPRED1
Gene Alias
FLJ33903, NFLS
Gene Description
sprouty-related, EVH1 domain containing 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq
Other Designations
EVH1/Sprouty domain containing protein|sprouty-related protein 1 with EVH-1 domain|suppressor of Ras/MAPK activation
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Interactome
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Pathway
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Disease
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Publication Reference
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Live simian immunodeficiency virus vaccine correlate of protection: immune complex-inhibitory fc receptor interactions that reduce target cell availability.
Smith AJ, Wietgrefe SW, Shang L, Reilly CS, Southern PJ, Perkey KE, Duan L, Kohler H, Muller S, Robinson J, Carlis JV, Li Q, Johnson RP, Haase AT.
The Journal of Immunology 2014 Sep; 193(6):3126.
Application：IHC-P, Monkey, Endocervical.
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Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.
Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M.
Oncogene 2006 May; 25(45):6056.
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Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.
Nature 2001 Aug; 412(6847):647.
Application：IF, WB-Ce, Mouse, C2C12 cells.
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Inhibition of angiogenesis by a mouse sprouty protein.
Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL.
The Journal of Biological Chemistry 2001 Feb; 276(6):4128.
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Live simian immunodeficiency virus vaccine correlate of protection: immune complex-inhibitory fc receptor interactions that reduce target cell availability.
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