JPH1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of JPH1.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human JPH1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of JPH1 in 293 cell lysate with JPH1 polyclonal antibody (Cat # PAB16568) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of JPH1 in mouse skeletal muscle tissue with JPH1 polyclonal antibody (Cat # PAB16568) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — JPH1
Entrez GeneID
56704Protein Accession#
AAI39833Gene Name
JPH1
Gene Alias
DKFZp762L0313, JP-1, JP1
Gene Description
junctophilin 1
Omim ID
605266Gene Ontology
HyperlinkGene Summary
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq
Other Designations
junctophilin type1|mitsugumin72
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Interactome
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Disease
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Publication Reference
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Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H.
The EMBO Journal 2007 Mar; 26(7):1924.
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Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.
Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN.
The Journal of Biological Chemistry 2007 Mar; 282(12):8667.
Application:WB, Rabbit, Rabbit skeletal muscle.
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Coexpression of junctophilin type 3 and type 4 in brain.
Nishi M, Sakagami H, Komazaki S, Kondo H, Takeshima H.
Brain Research. Molecular Brain Research 2003 Oct; 118(1-2):102.
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Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
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