SPRED2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPRED2.
Immunogen
A synthetic peptide corresponding to internal region 13 amino acids of human SPRED2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SPRED2 in human small intestine tissue lysate with SPRED2 polyclonal antibody (Cat # PAB16560) at (A) 1 and (B) 2 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPRED2
Entrez GeneID
200734Protein Accession#
NP_861449Gene Name
SPRED2
Gene Alias
FLJ21897, FLJ31917, MGC163164, Spred-2
Gene Description
sprouty-related, EVH1 domain containing 2
Omim ID
609292Gene Ontology
HyperlinkGene Summary
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM
Other Designations
sprouty protein with EVH-1 domain 2, related sequence|sprouty-related protein with EVH-1 domain 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.
Nature 2001 Aug; 412(6847):647.
Application:Func, IF, IP, WB, Mouse, Rat, C2C12, PC-12 cells.
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Inhibition of angiogenesis by a mouse sprouty protein.
Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL.
The Journal of Biological Chemistry 2001 Feb; 276(6):4128.
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Sprouty, an intracellular inhibitor of Ras signaling.
Casci T, Vinos J, Freeman M.
Cell 1999 Mar; 96(5):655.
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Spred is a Sprouty-related suppressor of Ras signalling.
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