CAPN6 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 polyclonal antibody (Cat # PAB16543) at (Lane 1) 0.5 and (Lane 2) 1 ug/mL .
Immunohistochemistry
Immunohistochemistry of CAPN6 in human lung tissue with CAPN6 polyclonal antibody (Cat # PAB16543) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAPN6.
Immunogen
A synthetic peptide corresponding to C-terminus 18 amino acids of human CAPN6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 polyclonal antibody (Cat # PAB16543) at (Lane 1) 0.5 and (Lane 2) 1 ug/mL .Immunohistochemistry
Immunohistochemistry of CAPN6 in human lung tissue with CAPN6 polyclonal antibody (Cat # PAB16543) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — CAPN6
Entrez GeneID
827Protein Accession#
NP_055104Gene Name
CAPN6
Gene Alias
CANPX, CAPNX, CalpM, DJ914P14.1
Gene Description
calpain 6
Omim ID
300146Gene Ontology
HyperlinkGene Summary
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. It also lacks critical active site residues and thus is suggested to be proteolytically inactive. [provided by RefSeq
Other Designations
OTTHUMP00000023858|calpain-like protease|calpamodulin
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Interactome
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Disease
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Publication Reference
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Identification of host proteins required for HIV infection through a functional genomic screen.
Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ.
Science 2008 Jan; 319(5865):921.
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Topological variation in single-gene phylogenetic trees.
Castresana J.
Genome Biology 2007 Jun; 8(6):216.
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Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.
Tonami K, Kurihara Y, Aburatani H, Uchijima Y, Asano T, Kurihara H.
Molecular and Cellular Biology 2007 Apr; 27(7):2548.
Application：IF, WB-Tr, Mouse, NIH3T3 cells.
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Identification of host proteins required for HIV infection through a functional genomic screen.
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