TICAM2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TICAM2 in the (Lane 1) absence and (Lane 2) presence of immunizing peptide in human lung, (Lane 3) mouse lung and (Lane 4) rat lung lysate using TICAM2 polyclonal antibody (Cat # PAB16535) at 1 ug/mL . Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of TICAM2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and TICAM2 polyclonal antibody (Cat # PAB16535) (bottom left, right) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TICAM2.
Immunogen
A synthetic peptide corresponding to amino acids 87-103 of human TICAM2.
Sequence
EDDTDEALRVQNLLQDD
Host
Rabbit
Reactivity
Chimpanzee, Dog, Horse, Human, Macaque, Mouse, Rat
Specificity
The amino acid sequence used as immunogen is 100% homologous in human, chimpanzee and rhesus monkey, 88% homologous in dog, mouse and rat and 82% homologous in horse.
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TICAM2 in the (Lane 1) absence and (Lane 2) presence of immunizing peptide in human lung, (Lane 3) mouse lung and (Lane 4) rat lung lysate using TICAM2 polyclonal antibody (Cat # PAB16535) at 1 ug/mL . Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of TICAM2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and TICAM2 polyclonal antibody (Cat # PAB16535) (bottom left, right) at 5 ug/mL . -
Gene Info — TICAM2
Entrez GeneID
353376Protein Accession#
AAO74498Gene Name
TICAM2
Gene Alias
MGC129876, MGC129877, TICAM-2, TIRAP3, TIRP, TRAM
Gene Description
toll-like receptor adaptor molecule 2
Omim ID
608321Gene Ontology
HyperlinkGene Summary
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM
Other Designations
OTTHUMP00000162868|TIR domain-containing adaptor molecule 2|TIR-containing adapter molecule 2|TIR-containing adapter molecule-2|TIRAP3a|TRIF-related adaptor molecule|Toll/interleukin-1 receptor (TIR) domain-containing adapter protein|cytoplasmic adaptor
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Pathway
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Disease
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Publication Reference
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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK.
Circulation Research 2006 May; 98(9):1134.
Application：WB-Ce, Human, Bovine, Mouse, BAECs, HUVECs, Human saphenous vein ECs, Mouse bone marrow cells, THP-1 cells.
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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
Nature Immunology 2003 Nov; 4(11):1144.
Application：IP-WB, WB-Tr, Mouse, Marcophages.
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.
The Journal of Experimental Medicine 2003 Sep; 198(7):1043.
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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
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