PDE6A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human retina with PDE6A polyclonal antibody (Cat # PAB16433).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PDE6A.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human PDE6A.
Host
Rabbit
Reactivity
Hamster, Human, Monkey, Mouse, Rat
Specificity
N-terminal region of human.
Form
Liquid
Purification
Immunoaffinity purification
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human retina with PDE6A polyclonal antibody (Cat # PAB16433). -
Gene Info — PDE6A
Entrez GeneID
5145Protein Accession#
P16499Gene Name
PDE6A
Gene Alias
CGPR-A, PDEA
Gene Description
phosphodiesterase 6A, cGMP-specific, rod, alpha
Omim ID
180071Gene Ontology
HyperlinkGene Summary
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq
Other Designations
cGMP phosphodiesterase alpha subunit|phosphodiesterase 6A, alpha subunit|rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha|rod photoreceptor cGMP phosphodiesterase alpha subunit
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Interactome
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Disease
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