PTPRM polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPRM.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human PTPRM.
Host
Rabbit
Reactivity
Bovine, Dog, Human, Monkey, Rabbit
Specificity
Internal domain of human.
Form
Liquid
Purification
Immunoaffinity purification
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human retina with PTPRM polyclonal antibody (Cat # PAB16289). -
Gene Info — PTPRM
Entrez GeneID
5797Protein Accession#
P28827Gene Name
PTPRM
Gene Alias
MGC166994, PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
Gene Description
protein tyrosine phosphatase, receptor type, M
Omim ID
176888Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq
Other Designations
protein tyrosine phosphatase mu|protein tyrosine phosphatase, receptor type, mu polypeptide
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