ERBB4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERBB4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human ERBB4.
Host
Rabbit
Reactivity
Human
Specificity
Internal domain of human.
Form
Liquid
Purification
Immunoaffinity purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15-30 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human glomerulus with ERBB4 polyclonal antibody (Cat # PAB16287). -
Gene Info — ERBB4
Entrez GeneID
2066Protein Accession#
Q15303Gene Name
ERBB4
Gene Alias
HER4, MGC138404, p180erbB4
Gene Description
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Omim ID
600543Gene Ontology
HyperlinkGene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4|v-erb-a erythroblastic leukemia v
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