Rabbit polyclonal antibody raised against partial recombinant IL6R.
Immunogen:
Recombinant protein corresponding to extracellular region of human IL6R.
Host:
Rabbit
Reactivity:
Human
Form:
Lyophilized
Purification:
Protein A affinity chromatography
Isotype:
IgG
Recommend Usage:
ELISA (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Storage Buffer:
Lyophilized from PBS, pH 7.4.
Storage Instruction:
The lyophilized antibody is stable for at least 1 year from date of receipt at -20°C. After reconstitution with 0.01 M PBS, pH 7.4 or other diluents, this antibody can be stored in working aliquots at 2°C- 8°C for one month, or at -20°C for six months without detectable loss of activity. Aliquot to avoid repeated freezing and thawing.
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq