NOTCH1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.
Immunogen
A synthetic peptide corresponding to N-terminus of human NOTCH1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOTCH1
Entrez GeneID
4851Gene Name
NOTCH1
Gene Alias
TAN1, hN1
Gene Description
Notch homolog 1, translocation-associated (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq
Other Designations
OTTHUMP00000022594|neurogenic locus notch homolog protein 1|notch1|translocation-associated notch protein TAN-1
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Interactome
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Pathway
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Disease
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Publication Reference
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High-resolution crystal structure of the human Notch 1 ankyrin domain.
Ehebauer MT, Chirgadze DY, Hayward P, Martinez Arias A, Blundell TL.
The Biochemical Journal 2005 Nov; 392(Pt 1):13.
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Structural and functional properties of the human notch-1 ligand binding region.
Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK.
Structure 2004 Dec; 12(12):2173.
Application:Flow Cyt, Recombinant protein.
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Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.
Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC.
Biochemistry 2003 Jun; 42(23):7061.
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High-resolution crystal structure of the human Notch 1 ankyrin domain.
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