BRWD2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BRWD2.
Immunogen
A synthetic peptide corresponding to N-terminus of human BRWD2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BRWD2
Entrez GeneID
55717Gene Name
BRWD2
Gene Alias
DKFZp434L1715, DR11, FLJ42531, WDR11, WDR15
Gene Description
bromodomain and WD repeat domain containing 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq
Other Designations
OTTHUMP00000020620|WD repeat domain 11|WD repeat domain 15|WD40 repeat domain 11 protein
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Interactome
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Disease
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Publication Reference
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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M.
Molecular Cell 2008 Aug; 31(3):438.
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Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Daisuke Nakajima, Noriko Okazaki, Hisashi Yamakawa, Reiko Kikuno, Osamu Ohara, Takahiro Nagase.
DNA Research 2002 Jun; 9(3):99.
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A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.
Chernova OB, Hunyadi A, Malaj E, Pan H, Crooks C, Roe B, Cowell JK.
Oncogene 2001 Aug; 20(38):5378.
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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
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