TRIM22 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRIM22.
Immunogen
A synthetic peptide corresponding to C-terminus of human TRIM22.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRIM22
Entrez GeneID
10346Gene Name
TRIM22
Gene Alias
GPSTAF50, RNF94, STAF50
Gene Description
tripartite motif-containing 22
Omim ID
606559Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. [provided by RefSeq
Other Designations
OTTHUMP00000069823|stimulated trans-acting factor (50 kDa)|tripartite binding motif 22|tripartite motif protein TRIM22
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Interactome
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Publication Reference
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Different subcellular localisations of TRIM22 suggest species-specific function.
Herr AM, Dressel R, Walter L.
Immunogenetics 2009 Feb; 61(4):271.
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Identification of TRIM22 as a RING finger E3 ubiquitin ligase.
Duan Z, Gao B, Xu W, Xiong S.
Biochemical and Biophysical Research Communications 2008 Sep; 374(3):502.
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HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A.
Nature Medicine 2003 Feb; 9(2):191.
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Different subcellular localisations of TRIM22 suggest species-specific function.
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