SLC39A4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC39A4.
Immunogen
A synthetic peptide corresponding to N-terminus of human SLC39A4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SLC39A4
Entrez GeneID
55630Gene Name
SLC39A4
Gene Alias
AEZ, FLJ20327, MGC74741, ZIP4
Gene Description
solute carrier family 39 (zinc transporter), member 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica, a rare inherited defect in the absorption of dietary zinc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acrodermatitis enteropathica, zinc-deficiency type|zinc transporter ZIP4
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Interactome
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Disease
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Publication Reference
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Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.
Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ, Petris MJ.
The Journal of Biological Chemistry 2004 Feb; 279(6):4523.
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Novel SLC39A4 mutations in acrodermatitis enteropathica.
Nakano A, Nakano H, Nomura K, Toyomaki Y, Hanada K.
The Journal of Investigative Dermatology 2003 Jun; 120(6):963.
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A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.
Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J.
American Journal of Human Genetics 2002 Jul; 71(1):66.
Application：IF, IHC-Fr, Mouse , Mouse colon.
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Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.
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