BRIP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BRIP1.
Immunogen
A synthetic peptide corresponding to C-terminus of human BRIP1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BRIP1
Entrez GeneID
83990Gene Name
BRIP1
Gene Alias
BACH1, FANCJ, FLJ90232, MGC126521, MGC126523, OF
Gene Description
BRCA1 interacting protein C-terminal helicase 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq
Other Designations
BRCA1-associated C-terminal helicase 1|BRCA1-binding helicase-like protein BACH1|BRCA1-interacting protein 1
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Interactome
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Disease
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Publication Reference
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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.
Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, Andreassen PR, Cantor SB.
Cancer Cell 2005 Sep; 8(3):255.
Application:IP, WB, Human, FA-J, Human mammary epithelial cells, MCF-7 cells.
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.
PNAS 2004 Aug; 101(33):12130.
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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM.
PNAS 2004 Feb; 101(8):2357.
Application:IP, Human, HeLa cells.
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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.
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