RRM2B (phospho S72) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of RRM2B.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S72 of human RRM2B.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — RRM2B
Entrez GeneID
50484Gene Name
RRM2B
Gene Alias
DKFZp686M05248, MGC102856, MGC42116, p53R2
Gene Description
ribonucleotide reductase M2 B (TP53 inducible)
Omim ID
604712Gene Ontology
HyperlinkOther Designations
p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 long form|p53-inducible ribonucleotide reductase small subunit 2 short form gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene.
Bornstein B, Area E, Flanigan KM, Ganesh J, Jayakar P, Swoboda KJ, Coku J, Naini A, Shanske S, Tanji K, Hirano M, DiMauro S.
Neuromuscular Disorders 2008 Jun; 18(6):453.
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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.
Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chretien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rotig A.
Nature Genetics 2007 Jun; 39(6):776.
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The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53.
Zhou B, Liu X, Mo X, Xue L, Darwish D, Qiu W, Shih J, Hwu EB, Luh F, Yen Y.
Cancer Research 2003 Oct; 63(20):6583.
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Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene.
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