MAPK7 (phospho S731/T733) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAPK7.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S731/T733 of human MAPK7.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAPK7
Entrez GeneID
5598Gene Name
MAPK7
Gene Alias
BMK1, ERK4, ERK5, PRKM7
Gene Description
mitogen-activated protein kinase 7
Omim ID
602521Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq
Other Designations
BMK1 kinase|OTTHUMP00000065906|big MAP kinase 1|extracellular-signal-regulated kinase 5
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Interactome
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Pathway
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Disease
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Publication Reference
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A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
Sawhney RS, Liu W, Brattain MG.
Journal of Cellular Physiology 2009 Apr; 219(1):152.
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ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.
Zen K, Yasui K, Nakajima T, Zen Y, Zen K, Gen Y, Mitsuyoshi H, Minami M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T, Yoshikawa T.
Genes, Chromosomes & Cancer 2009 Feb; 48(2):109.
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Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells.
Zhao Z, Geng J, Ge Z, Wang W, Zhang Y, Kang W.
Molecular and Cellular Biochemistry 2008 Nov; 322(1-2):171.
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A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
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