DDX58 (phospho T170) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of DDX58.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding T170 of human DDX58.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — DDX58
Entrez GeneID
23586Gene Name
DDX58
Gene Alias
DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG-I
Gene Description
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Omim ID
609631Gene Ontology
HyperlinkGene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq
Other Designations
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I|OTTHUMP00000021185|OTTHUMP00000045225|RNA helicase RIG-I|retinoic acid-inducible gene I
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Interactome
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Disease
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Publication Reference
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Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF.
Molecular Cell 2017 Oct; 68(2):293.
Application:WB-Ce, Human, THP-1 NE cells.
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Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases.
Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB.
Cell Host & Microbe 2014 Jul; 16(1):31.
Application:Flow Cyt, Human, Dendritic cells.
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SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.
The EMBO Journal 2005 Nov; 24(23):4018.
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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
Seth RB, Sun L, Ea CK, Chen ZJ.
Cell 2005 Sep; 122(5):669.
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Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
Sumpter R Jr, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M Jr.
Journal of Virology 2005 Mar; 79(5):2689.
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Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
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