UNC5C polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
UNC5C polyclonal antibody (Cat # PAB15681) (3.8 ug/mL) staining of paraffin embedded human cerebral cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunofluorescence
UNC5C polyclonal antibody (Cat # PAB15681) (50 ug/mL) staining of islets in mouse pancreas. Citrate antigen retrieval. Detected by immunofluorescence.
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of UNC5C.
Immunogen
A synthetic peptide corresponding to internal region of human UNC5C.
Sequence
NCTVSEEPTGID
Host
Goat
Theoretical MW (kDa)
103
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
UNC5C polyclonal antibody (Cat # PAB15681) (3.8 ug/mL) staining of paraffin embedded human cerebral cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Immunofluorescence
UNC5C polyclonal antibody (Cat # PAB15681) (50 ug/mL) staining of islets in mouse pancreas. Citrate antigen retrieval. Detected by immunofluorescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — UNC5C
Entrez GeneID
8633Protein Accession#
NP_003719.2Gene Name
UNC5C
Gene Alias
UNC5H3
Gene Description
unc-5 homolog C (C. elegans)
Omim ID
603610Gene Ontology
HyperlinkGene Summary
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq
Other Designations
homolog of C. elegans transmembrane receptor Unc5|unc5 (C.elegans homolog) c|unc5C
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Interactome
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Pathway
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Disease
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Publication Reference
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Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A.
Gastroenterology 2007 Dec; 133(6):1849.
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Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
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