TREX2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of TREX2.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human TREX2.
Sequence
C-HRSSLENPEHDES
Host
Goat
Theoretical MW (kDa)
25.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TREX2 polyclonal antibody (Cat # PAB15677) (3.8 ug/mL) staining of paraffin embedded human breast. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TREX2
Entrez GeneID
11219Protein Accession#
NP_542432.2Gene Name
TREX2
Gene Alias
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Gene Description
three prime repair exonuclease 2
Omim ID
300370Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq
Other Designations
3'-5' exonuclease|OTTHUMP00000025920|OTTHUMP00000025922
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Interactome
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Disease
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Publication Reference
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The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T.
The Journal of Biological Chemistry 2007 Apr; 282(14):10537.
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The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
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