SRD5A2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of SRD5A2.
Immunogen
A synthetic peptide corresponding to human SRD5A2.
Sequence
C-KMFEDYPKSRK
Host
Goat
Theoretical MW (kDa)
28.4
Reactivity
Human
Specificity
Approximately 29 KDa band observed in human testis lysates (calculated MW of 28.4 KDa according to NP_000339.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SRD5A2 polyclonal antibody (Cat # PAB15668) (1 ug/mL) staining of human testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SRD5A2
Entrez GeneID
6716Protein Accession#
NP_000339.2Gene Name
SRD5A2
Gene Alias
MGC138457
Gene Description
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq
Other Designations
3-oxo-5 alpha-steroid 4-dehydrogenase 2|steroid 5-alpha-reductase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men.
Torkko KC, van Bokhoven A, Mai P, Beuten J, Balic I, Byers TE, Hokanson JE, Norris JM, Baron AE, Lucia MS, Thompson IM, Leach RJ.
Clinical Cancer Research 2008 May; 14(10):3223.
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VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men.
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