KCNQ3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of KCNQ3.
Immunogen
A synthetic peptide corresponding to human KCNQ3.
Sequence
C-SDSVWTPSNKPI
Host
Goat
Theoretical MW (kDa)
96.7
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNQ3
Entrez GeneID
3786Protein Accession#
NP_004510.1Gene Name
KCNQ3
Gene Alias
BFNC2, EBN2, KV7.3
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 3
Gene Ontology
HyperlinkGene Summary
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). [provided by RefSeq
Other Designations
potassium channel, voltage-gated, subfamily Q, member 3|potassium voltage-gated channel KQT-like protein 3
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Interactome
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Disease
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Publication Reference
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Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.
Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ.
The Journal of Biological Chemistry 2007 Apr; 282(16):12135.
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Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.
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