KCNJ1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
KCNJ1 polyclonal antibody (Cat # PAB15638) (1 ug/mL) staining of human kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of KCNJ1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human KCNJ1.
Sequence
C-DQININFVVDAGNEN
Host
Goat
Theoretical MW (kDa)
44.8, 42.7
Reactivity
Human
Specificity
Approximately 45 KDa band observed in human, mouse and rat kidney lysates (calculated MW of 44.8 KDa according to NP_000211.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
KCNJ1 polyclonal antibody (Cat # PAB15638) (1 ug/mL) staining of human kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNJ1
Entrez GeneID
3758Protein Accession#
NP_000211.1Gene Name
KCNJ1
Gene Alias
KIR1.1, ROMK, ROMK1
Gene Description
potassium inwardly-rectifying channel, subfamily J, member 1
Gene Ontology
HyperlinkGene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|OTTHUMP00000045938|inwardly rectifying K+ channel|potassium inwardly-rectifying channel J1
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Interactome
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Disease
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Publication Reference
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Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP.
Nature Genetics 2008 May; 40(5):592.
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Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
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