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Last updated: 2017/9/17
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HMGCR polyclonal antibody

  • Catalog # : PAB15633
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised aganist synthetic peptide of HMGCR.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human HMGCR.
  • Sequence:
  • C-ADPSPQNSTADTSK
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 97.5
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:8000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 3156
  • Gene Name:
  • HMGCR
  • Gene Alias:
  • -
  • Gene Description:
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Gene Summary:
  • HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH),hydroxymethylglutaryl-CoA reductase
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