HAMP polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of HAMP.
Immunogen
A synthetic peptide corresponding to human HAMP.
Sequence
TSGSVFPQQTGQLAE-C
Host
Goat
Theoretical MW (kDa)
9.41
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HAMP
Entrez GeneID
57817Protein Accession#
NP_066998.1Gene Name
HAMP
Gene Alias
HEPC, HEPCIDIN, HFE2B, LEAP-1, LEAP1, PLTR
Gene Description
hepcidin antimicrobial peptide
Gene Ontology
HyperlinkGene Summary
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq
Other Designations
liver-expressed antimicrobial peptide|putative liver tumor regressor
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Interactome
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Disease
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Publication Reference
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Increased hepcidin expression in colorectal carcinogenesis.
Ward DG, Roberts K, Brookes MJ, Joy H, Martin A, Ismail T, Spychal R, Iqbal T, Tselepis C.
World Journal of Gastroenterology 2008 Mar; 14(9):1339.
Application：Func, IHC-P, Human, Human colorectal cancer, urine sample.
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Increased hepcidin expression in colorectal carcinogenesis.
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