CHRFAM7A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of CHRFAM7A.
Immunogen
A synthetic peptide corresponding to human CHRFAM7A.
Sequence
QKYCIYQHFQFQ
Host
Goat
Theoretical MW (kDa)
46.2, 35.5
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHRFAM7A
Entrez GeneID
89832Protein Accession#
NP_647536.1Gene Name
CHRFAM7A
Gene Alias
CHRNA7, CHRNA7-DR1, D-10, MGC120482, MGC120483
Gene Description
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Omim ID
609756Gene Ontology
HyperlinkGene Summary
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq
Other Designations
CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion|CHRNA7-FAM7A fusion|alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid|alpha-7 nicotinic cholinergic rec
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Disease
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Publication Reference
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Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type.
Martin LF, Leonard S, Hall MH, Tregellas JR, Freedman R, Olincy A.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the Official Publication of 2007 Jul; 144B(5):611.
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Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type.
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