CHN2 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CHN2 polyclonal antibody (Cat # PAB15616) (3.8 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised aganist synthetic peptide of CHN2.
Immunogen
A synthetic peptide corresponding to C-terminus of human CHN2.
Sequence
C-QILIENEDVLF
Host
Goat
Theoretical MW (kDa)
38.2, 53.9
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_004058.1; NP_001035025.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CHN2 polyclonal antibody (Cat # PAB15616) (3.8 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHN2
Entrez GeneID
1124Protein Accession#
NP_001035025.1Gene Name
CHN2
Gene Alias
ARHGAP3, BCH, MGC138360, RHOGAP3
Gene Description
chimerin (chimaerin) 2
Omim ID
602857Gene Ontology
HyperlinkGene Summary
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
beta chimerin|rho-GTPase-activating protein 3
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Interactome
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Disease
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Publication Reference
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T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.
Siliceo M, Merida I.
The Journal of Biological Chemistry 2009 Feb; 284(17):11354.
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T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.
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