Western blot of MCF-7 cell extracts with CBX1 polyclonal antibody (Cat # PAB15581) at 1000 fold dilution.
Immunofluorescent staining of CBX1 in baby hamster kidney cells with CBX1 polyclonal antibody (Cat # PAB15581). Cells were fixed with para-formaldehyde. The second antibody was Alexa Fluor 594 conjugated goat anti-rabbit IgG.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
heterochromatin protein 1-beta,heterochromatin protein p25 beta,modifier 1 protein