CBX5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Detection of CBX5 protein by Western blotting of crude extract of MCF-7 cells.
CBX5 polyclonal antibody (Cat # PAB15580) was diluted 1000 fold before use.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CBX5.
Immunogen
A synthetic peptide corresponding to amino acids 179-191 of human CBX5.
Sequence
EDAENKEKETAKS
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:1000-1:3000)
Immunofluorescence (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 120 mM sodium phosphate buffer, pH 7.4 (50% glycerol)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Detection of CBX5 protein by Western blotting of crude extract of MCF-7 cells.
CBX5 polyclonal antibody (Cat # PAB15580) was diluted 1000 fold before use.Immunofluorescence
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Gene Info — CBX5
Entrez GeneID
23468Gene Name
CBX5
Gene Alias
HP1, HP1A
Gene Description
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
Omim ID
604478Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
HP1-ALPHA|HP1Hs alpha|antigen p25|heterochromatin protein 1 homolog alpha|heterochromatin protein 1-alpha
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Interactome
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Publication Reference
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The Heterochromatin Protein 1 family.
Lomberk G, Wallrath L, Urrutia R.
Genome Biology 2006 Jul; 7(7):228.
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The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells.
Wang F, Koyama N, Nishida H, Haraguchi T, Reith W, Tsukamoto T.
Molecular and Cellular Biology 2006 Jun; 26(11):4028.
Application：IF, ChIP, Mouse, Clone 2 cells.
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Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins.
Kametaka A, Takagi M, Hayakawa T, Haraguchi T, Hiraoka Y, Yoneda Y.
Genes to Cells 2002 Dec; 7(12):1231.
Application：IF, Human, HeLa cells.
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The Heterochromatin Protein 1 family.
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