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Last updated: 2016/12/11
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RANBP2 polyclonal antibody

  • Catalog # : PAB15577
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of RANBP2.
  • Immunogen:
  • A synthetic peptide corresponding to human RANBP2.
  • Sequence:
  • SKAPKSGFEGMFTKKE
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with human RANBP2.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In antiserum (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of HeLa cell lysate with RANBP2 polyclonal antibody (Cat # PAB15577). Primary antibody at a 1 : 1000 dilution.
  • Immunohistochemistry
  • Immunohistochemistry
  • Para-formaldehyde fixed HeLa cells stained with RANBP2 polyclonal antibody (Cat # PAB15577) (1 : 2000 dilution).
  • Immunocytochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 5903
  • Gene Name:
  • RANBP2
  • Gene Alias:
  • NUP358,TRP1,TRP2
  • Gene Description:
  • RAN binding protein 2
  • Gene Summary:
  • RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq
  • Other Designations:
  • P270,nuclear pore complex protein Nup358,nucleoporin 358,transformation-related protein 2
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