Products

Western Blot (Cell lysate)

Western blot analysis of HeLa cell lysate with RANBP2 polyclonal antibody (Cat # PAB15577). Primary antibody at a 1 : 1000 dilution.

Immunocytochemistry

Immunoprecipitation

Entrez GeneID

5903

Protein Accession#

P49792

Gene Name

RANBP2

Gene Alias

NUP358, TRP1, TRP2

Gene Description

RAN binding protein 2

Omim ID

601181

Gene Ontology

Hyperlink

Gene Summary

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq

Other Designations

P270|nuclear pore complex protein Nup358|nucleoporin 358|transformation-related protein 2